血清胱抑素C测定对早期糖尿病肾病的诊断价值

Determination of Serum Cystatin C in Diagnosis of Early Diabetic Nephropathy

目的观察血清胱抑素C测定对早期糖尿病肾病的诊断价值。方法对2015年1月—2016年6月该院189例糖尿病患者血清胱抑素C及尿微量蛋白进行检测,尿微量白蛋白0~30 mg/L为正常,Cys-C 0.55~1.05 mg/L为正常范围。超过此正常范围即为异常。结果 189例患者尿微量白蛋白值为（32.5±5.8）mg/L,阳性检出率为24.3%（46/189）,血清胱抑素C测定值为（1.35±0.65）mg/L,阳性检出率为41.2%（78/189）,血清胱抑素C测定阳性检出率高于尿微量白蛋白测定阳性检出率,P〈0.05。结论血清胱抑素C测定是诊断糖尿病肾病的灵敏指标,可以及早监测糖尿病肾病,尽早干预,改善预后。

Objective To investigate the diagnostic value of determination of serum cystatin C in early diabetic nephropathy.Methods During January 2015 to June 2016, 189 cases of serum cystatin C in patients with diabetes and albuminuria, microalbuminuria 0-30mg/L as normal, Cys-C 0.55-1.05mg/L in the normal range. Beyond this normal range is the exception.Results 189 cases of patients with urinary albumin values for（32.5±5.8） mg/L, the positive rate was 24.3%（46/189）, serum cystatin C measurement value is（1.35±0.65） mg/L, the positive rate was 41.2%（78/189）, determination of serum cystatin C positive rate was higher than that of microalbuminuria positive rate. P〈0.05. Conclusion Determination of serum cystatin C is a sensitive index of early diagnosis of diabetic nephropathy, diabetic nephropathy monitoring, early intervention to improve the prognosis.