阿司匹林对斑马鱼胃肠道的毒性研究

Toxicity of aspirin to gastrointestinal tract of zebrafish

以斑马鱼作为动物模型,通过胃肠道蠕动功能分析、胃肠道内皮细胞分泌功能检测和肠粘膜组织形态学观察等,对阿司匹林的胃肠道毒性做了初步分析。研究发现,阿司匹林浓度为50μg/m L时,可以加快斑马鱼胃肠道的蠕动;浓度为50μg/m L或100μg/m L时,虽然斑马鱼肠粘膜的组织形态未受损害,但是位于肠粘膜上的杯状细胞的分泌功能会受到影响。

We performed a preliminary analysis of gastrointestinal toxicity of aspirin through analysis of peristalsis,detection of secretion functionality of gastrointestinal endothelial cells and histomorphology of intestinal mucosa with zebrafish as animal model. We discover that aspirin concentration of 50 μg/mL can improve the peristalsis. Aspirin concentration of 50 μg/mL or 100 μg/mL will impair secretion functionality of goblet cells on intestinal mucosa though routine HE staining among intestinal mucosa does not change.