结合生物体形态学信息实现功能血流成像的近红外漫射光新技术

Near-infrared diffuse optical technology for functional blood flow imaging through integrating the morphological information of biological tissues

近红外漫射光相关断层成像(DCT)是近年发展起来的基于光场相关原理的血流成像技术,我们针对该技术提出的新型研究方案获得2016年"数字诊疗装备研发"的立项支持。项目目标是结合生物体形态学信息建立新的DCT血流成像模型,并将共性的图像重建方法与DCT物理特征相结合改进重建算法,由此获得精确和稳定的血流成像。拟使用计算机仿真和仿体实验相结合的方式优化和定量评测DCT系统,并用头颈部癌、乳腺癌、通过体位改变脑部血流等病理和生理的人体试验对DCT系统进行全面的临床评测。

Near-infrared diffuse correlation tomography （DCT） is an innovative technology developed in recent years based on the theory of light electric field correlation, aiming to achieve blood flow imaging. The proposed research project on the further development of DCT technology is funded by ＂Digital Medical Equipment Research and Development ＂ in National Key Research and Development Program of China. The project aims to establish a new physical model of DCT for blood flow imaging through integrating the morphological information derived from biological tissues. The image reconstruction algorithms will be improved by combining the general imaging approaches and DCT physical characteristics, so as to extract accurate and robust imaging of blood flow. The computer simulation and phantom experiment will be used to optimize and evaluate the proposed DCT system. For clinical evaluation, the DCT system will be extensively applied on human subjects in several physiological or pathological situations, such as head-neck cancer, breast cancer as well as the brain with flow changed by posture alterations.