“看清”颅内血管——高分辨率经颅超声诊疗系统

High-resolution transcranial ultrasound diagnosis and treatment system for cerebral vessels

超声引导的脑部疾病治疗一直是科学家研究和关注的重点,超声监控在基于微泡介导的血脑屏障开放和脑部血管溶栓过程中具有独特优势。针对经颅超声在探测灵敏度、微小血管造影成像和血流灌注参量成像的分辨率和治疗过程中瞬态实时监控等方面的不足,本次首批获国家科技专项计划支持的高分辨率经颅超声诊疗系统将实现小区域脉冲逆转谐波造影成像/灌注参量成像、超时空分辨率微泡及空化成像,有望填补我国数字化诊疗设备在该领域的空白,为临床脑部疾病诊断和治疗提供革命性的技术手段。

Ultrasound-guided brain disorder treatment has been the focus of research and attention. Ultrasound monitoring has unique advantages in the process of blood brain barrier opening and cerebral blood vessel thrombolysis mediated by microbubbles. Transcranial ultrasound has some deficiencies, including low detection sensitivity, low resolution for microvessel contrast imaging and perfusion parametric imaging, and lack of transient real-time monitoring. To overcome these shortages, in this project supported by the National Key Research and Development Program of China, a transducer and equipment system for high-resolution transcranial ultrasound is developed, achieving small region pulse inversion harmonic contrast imaging and perfusion parameter imaging, and spatial-temporal super-resolution active and passive imaging for cavitation bubbles. The proposed system is expected to fill the gaps in the field of digital medical equipment in China, to provide revolutionary technical means for the clinical diagnosis and treatment of brain diseases.