自体干细胞介入治疗糖尿病足临床效果观察

PTA combined with transplantation of autologous bone marrow stem cells for diabetic foot:observation of clinical effect

目的探讨经皮腔内血管成形术(PTA)联合自体骨髓干细胞(AMSC)移植治疗糖尿病足的临床效果。方法选取接受介入治疗的61例糖尿病足患者作为研究对象。根据手术方式分组,单纯PTA组26例,单纯AMSC组12例,PTA联合AMSC组23例。对比3组患者术后1、3、9个月疗效。结果术后9个月随访显示,联合组治疗总有效率优于PTA组和AMSC组(P<0.05),下肢血管狭窄复发率低于PTA组和AMSC组(P<0.05)。结论 PTA术联合AMSC治疗糖尿病足安全、有效,疗效优于单纯PTA术及单纯AMSC移植治疗。

Objective To investigate the clinical effect of percutaneous transluminal angioplasty （PTA） combined with transplantation of autologous marrow stem cells （AMSC） for diabetic foot. Methods A total of 61 patients with diabetic foot （83 diseased feet in total） were included in this study. According to the therapeutic methods, the patients were divided into pure PTA group （n=26）, pure AMSC group （n=12） and combination group （PTA＋AMSC, n=23）. The one-month, 3-month and 9-month curative effects of the three groups were compared. Results Follow-up examination at 9 months after treatment showed that the total effective rate of the combination group was significantly better than that of both PTA group and AMSC group （P〈0.05）. The recurrence rate of lower extremity vascular stenosis in the combination group was strikingly lower than that in both PTA group and AMSC group （P〈0.05）. Conclusion For the treatment of diabetic foot, combination use of PTA and transplantation of AMSC is safe and effective, its curative effect is superior to pure PTA as well as to pure AMSC.