长链非编码RNA MALATⅠ作为一种判断肿瘤预后的新型生物标志物的Meta分析

Long noncoding RNA MALATⅠ: a potential novel prognostic biomarkers in cancers based on Meta-analysis

目的：系统评价长链非编码RNA（long noncoding RNA,lnc RNA）转移相关性肺腺癌转录因子1（metastasisassociated lung adenocarcinoma transcript 1,MALAT1）作为一种新型生物标志物判断肿瘤预后的潜在价值。方法：计算机检索Cochrane Library,Medline,Embase,Pub Med等数据库中从建库到2015年8月1日前关于lnc RNA MALAT1表达与肿瘤患者总生存期相关性的英文文献。由2名研究者根据纳入与排除标准对文献进行独立筛选、提取资料和评价质量后,采用Rev Man 5.3软件进行Meta分析。结果：最终纳入10篇文献,共1 016例患者。Meta分析结果显示lnc RNA MALAT1的高表达与肿瘤患者的低总生存期密切相关（HR=2.08,95%CI：1.74～2.48,P〈0.001）。结论：Lnc RNA MALAT1可作为一种判断肿瘤预后的新型生物标志物。

Objective： To systematically review the potential value of long noncoding RNA（lnc RNA） metastasis-associated lung adenocarcinoma transcript 1（MALAT1） as a potential novel prognostic biomarker in cancers.Methods： Databases including Cochrane Library, Medline, Embase, Pub Med databases were searched for all English studies, which explored the correlation between lnc RNA MALAT1 expression and overall survival in tumors. Th e retrieval time was from inception to August 1, 2015. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, Meta-analysis was performed usingRevM an 5.3 software.Results： Ten studies covered a total of 1 016 patients. Meta-analysis showed that high expression of MALAT1 was significantly correlated to poor overall survival（OS） in patients with tumor（HR= 2.08, 95% CI 1.74 to 2.48, P0.001）. Conclusion： Lnc RNA MALAT1 might be a potential novel prognostic biomarker in tumor.