LPS诱导的奶牛子宫内膜细胞TLR4信号传导通路研究概况

LPS Induced TLR4 Signaling Pathway in Bovine Endometrial Cells

子宫内膜炎是奶牛产后细菌感染子宫而引起的产科疾病,严重影响奶牛业的健康发展。革兰阴性细菌中的大肠埃希菌是引起奶牛子宫内膜炎的主要致病菌,细菌脂多糖(lipopolysaccharide,LPS)是革兰阴性细菌细胞壁的重要组成成分,也是近年研究奶牛子宫内膜炎发病机制的重要诱导物。论文综述了LPS、Toll样受体(toll-like receptors,TLRs)及炎性因子,初步剖析了LPS诱导的炎症反应信号传导通路TLR4信号通路,为奶牛子宫内膜炎的研究提供参考。

Postpartum endometritis in cattle is an obstetric disease caused by bacterial infection, which is of economic importance since it negatively impacts on the dairy industry. Gram negative bacterium Escherichia coli is the main pathogen currently known to cause cow endometritis, and bacterial lipopolysaccharide （LPS） is a major component of the cell wall of Gram negative bacteria and recently also reported as an important inducer of cow endometritis pathogenesis. This paper reviewed the LPS Toll-like receptors（TLRs） and inflammatory factors as well as preliminary analysis of the LPS induced inflammatory response signaling pathway -TLR4 signaling pathway in order to provide reference for the study of cow endometritis.