影响瘢痕疙瘩术后复发相关因素分析

Analysis of factors on the recurrence of keloid scar after surgery

目的 探讨影响瘢痕疙瘩术后复发的相关因素。方法 回顾性分析2010年2月至2015年2月在我院诊断为瘢痕疙瘩并行手术切除201例,患者临床资料,包括性别、年龄、体重指数、放疗、家族史、感染、发病部位、激素、吸烟史、饮酒史、瘢痕大小等,应用Logistic回归分析研究影响瘢痕疙瘩术后复发相关因素。结果 随访6~23个月,中位随访时间17个月,总复发率为16.42%。瘢痕疙瘩复发与瘢痕大小（P=0.043）有关。放疗（P〈0.001）、激素（P=0.002）可以减少术后复发。结论 瘢痕疙瘩越大术后越容易复发,术后放疗及局部注射激素可以减少术后复发。

Objective To explore the factors on the recurrence of keloid scarring after surgery. Methods From Feb 2010 to Feb 2015, the clinical data of 201 patients with keloid who treated with surgery was collected. The data included gender, age, body mass index, radiation therapy, family history, infection, pathogenic site, hormones, smoking history, drinking history and scar size. The Logistic regression was used to analyze the factors on the recurrence of keloid scar. Results With median follow- up time of 17 months （ranged from 6 months to 23 months）, the overall recurrence rate was 16.42%. The recurrence of keloid scarring was affected by keloid size （P=0. 043）. radiation therapy （P〈0. 001） and hormones （P= 0. 002） could reduce the recurrence of keloid scarring after the surgery. Conclusion The greater of scar size, the easier of postoperative recurrence. Postoperative radiotherapy and local injection of hormone therapy could reduce recurrence of keloids.