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6-萘氧甲基-[1,3]二氧戊环并[4,5-g]喹啉-7-甲酸衍生物的合成（英文）

Synthesis of 6-naphthoxymethyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid derivatives
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摘要 介绍了通过6-氯甲基-[1,3]二氧戊环并[4,5-g]喹啉-7-甲酸乙酯与1-和2-萘酚的Williamson醚合成反应及其随后的酯水解反应,"一锅法"高收率的合成了结构新颖的含有萘环结构的喹啉化合物,即2-(萘氧甲基)喹啉-3-羧酸.这种新合成的化合物可以为开发有用的药物活性先导化合物提供很好的底物. A novel synthesis of naphthalene-containing quinolines,namely,2-（naphthoxymethyl）quinoline-3-carboxylic acids has been achieved in one-pot procedure in good yields through Williamson ether synthesis reaction of ethyl 6-（chloromethyl）-[1,3]dioxolo[4,5-g]quinoline-7-carboxylate with 1-and 2-naphthols followed by ethyl ester hydrolysis reaction.The new synthesized compounds would be good candidates for the development of compounds for use in medicinal chemistry.
作者 符鑫博 蔡巍 张红 李阳 常明琴
机构地区 渤海大学超精细化学品研究所 辽宁思百得医药科技有限公司
出处 《化学研究》 CAS 2016年第6期725-728,共4页 Chemical Research
基金 National Natural Science Foundation of China(21476028and 21402011)
关键词 萘 喹啉 Williamson醚合成 酯水解 一锅法 naphthalene quinoline Williamson ether synthesis ester hydrolysis one-pot
分类号 O625 [理学—有机化学]
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化学研究
2016年 第6期

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