碳量子点标记的硼替佐米缓释制剂的合成与应用

Synthesis and application of the carbon quantum dot-labeled bortezomib release agent

硼替佐米的肽硼酸与壳聚糖的羟基发生酯化反应生成肽硼酸酯,即得到硼替佐米-壳聚糖复合物;然后,该复合物中壳聚糖的氨基与碳量子点表面羧基发生静电吸附作用,将碳量子点吸附进入壳聚糖体系内,进而得到硼替佐米-壳聚糖-碳量子点复合纳米粒载体.此产物具有生物相容性、无毒副作用、荧光示踪及pH敏感等性质,在生物传感、生物医用材料、功能纳米材料,尤其是药物载体或制剂的控制释放方面,具有重要的研究意义和应用价值.

A bortezomib-chitosan complex was synthesized based on the esterification reaction between bortezomib peptide boronic acid and hydroxyl groups of chitosan;the carbon quantum dot enters the chitosan system through the electrostatic adsorption of the chitosan amino of bortezomib-chitosan complex and carboxyl of carbon quantum dot＇s surface to get bortezomibchitosan-carbon composite quantum dot nanoparticle carrier.This product has the nature of biocompatibility,non-toxic side effects,fluorescent tracer and pH sensitive.This product has important significance and application value in biosensors,biomaterials,functional nanomaterials,especially in terms of drug delivery and controlled release of drug formulation.