舒张性心力衰竭患者贫血与左室功能的关系及对预后的影响

THE ASSOCIATION BETWEEN ANEMIA WITH LEFT VENTRICULAR FUNCTION IN PATIENTS WITH DIASTOLIC HEART FAILURE AND ITS INFLUENCE ON THE PROGNOSIS

目的:探讨舒张性心力衰竭患者发生贫血与左室功能的关系,并研究贫血对舒张性心力衰竭患者预后的影响。方法:选取2010年8月至2015年8月陕西省宝鸡市中心医院心内科收治的舒张性心力衰竭合并轻度贫血患者81例(贫血组)、未合并贫血90例(非贫血组)为研究对象,对两组患者的左心室功能进行测定。贫血组按随机数字表法分为贫血研究组和贫血对照组两个亚组,贫血研究组给予右旋糖酐铁片治疗,贫血对照组不给予贫血干预治疗,观察两组患者1年预后情况。结果:贫血组患者的左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室后壁厚度(LVPWT)与非贫血组相比,差异均有统计学意义(均P<0.05)。贫血研究组患者Hb水平、再住院率、平均住院天数、NYHA分级,6min步行距离与贫血对照组比较,差异均有统计学意义(均P<0.05)。结论:舒张性心力衰竭患者发生贫血会导致左室功能降低,经过积极的纠正贫血治疗可有助于改善心力衰竭患者预后。

Objective： To analyze the association between the occurrence of anemia and left ventricular func- tion in patients with diastolic heart failure （DHF）. Methods： 81 cases of DHF patients in our hospital from August 2010 to August 2015 were selected and divided into anemia group （ n =81） and non-anemia group （ n =90）. The left ventricular function was assessed. The patients in the anemia group were randomized into two sub-groups：the research group in which the patients received iron dextran treatment, and the con- trol group in which the patients did not give any intervention. The prognosis of patients was compared. Re- sults： There were significant differences in the left ventricular ejection fraction （LVEF）, left ventricular end-diastolic dimension （LVEDD） and left ventricular posterior wall thickness （LVPWT） between the ane- mia and group and the non-anemia group （ P 〈0.05）. There were statistical differences in the haemoglobin B （Hb） level, the re-hospitalization rate, the average hospital days, NYHA grades and 6-min walking dis- tance between the research group and the control group （ P 〈0.05）. Conclusion： Anemia could contribute to reduced left ventricular function in DHF patients. The prognosis of DHF patients could be improved with the help of positive anemia treatment.