长链非编码核糖核酸与创面愈合

Long non-coding RNA and wound healing

创面的正常愈合是KC、Fb、细胞因子及ECM相互作用达到平衡状态的结果，包括部分重叠且相互协调的炎症期、增殖期和重塑期。当其平衡失调，一方面可能导致创面愈合延迟，形成慢性难愈性创面；另一方面也可能导致Fh过度增殖，形成增生性瘢痕，影响患者生活质量。从分子层面进一步认识创面愈合，寻找创面治疗的新靶点有重要意义。

Long non-coding RNA （lncRNA） is a class of RNA molecules longer than 200 nucleotides which does not encode proteins or only encode a few proteins, and it plays im- portant regulatory roles in the expression of genes at the epigenetic, transcriptional, and posttranscriptional levels. The recent reports suggest that lncRNA plays a significant role in growth and development of body, cellular biological processes including in cell proliferation, differentiation, migration, and apoptosis, and regulation of wound healing processes such as re-epithelialization, angiogenesis, and scar formation. The lncRNA has become a new research hotspot in wound healing. This article reviews the role of lncRNA in different stages of wound repair to get a further understanding of molecular mechanisms of wound healing and provide a new target spot for prevention and treatment of pathological scars and wound healing.