微粒与冠状动脉疾病关系的研究进展

Progress on Relationship between Microparticles and Coronary Artery Disease

冠状动脉疾病是全球范围内导致人们死亡的主要疾病之一,近年来微粒(MP)在冠状动脉疾病发生发展及风险预测中的作用越来越受到重视。MP是指许多不同类型细胞在激活或凋亡时通过质膜胞吐、出芽等方式而释放的小膜泡,可存在于健康人和不同病理状态患者血浆中。大量研究表明,MP在凝血、血栓形成、内皮功能紊乱、血管形成、炎症、细胞间沟通、动脉粥样硬化及斑块易损性等方面扮演着重要角色,还与微血管阻塞、心力衰竭及心源性猝死等密切相关。本文主要综述了MP与冠状动脉疾病关系的研究进展。

Coronary artery disease is one of worldwide leading causes of death, in recent years, researchers paid more and more attention to the role of microparticles （MPs） in the occurrence, development and risk prediction of coronary artery diseases. MPs belong to small membrane vesicles that released from many different types of cells by exoeytosis or budding through cell membrane in response to cellular activation or apoptosis ; MPs mainly exist in the plasma of healthy individuals mad of patients with different pathological states. Many studies suggested that MPs play important roles in blood coagulation process, thrombosis, endothelial dysfunction, vascularization, inflammation, intercellular communication, atherosclerosis and plaque vulnerability, have close associations with microvascular obstruction, heart failure and sudden cardiac death. This paper mainly reviewed the progress on relationship between MPs and coronary artery disease.