醒脑静注射液辅助经鼻正压通气治疗肺性脑病的临床疗效及其对患者神经功能的影响

Clinical Effect and Impact on Neurological Function of Xingnaojing Injection in the Adjuvant Therapy for Pulmonary Encephalopathy Patients Undergoing Nasal Positive Airway Pressure Ventilation

目的分析醒脑静注射液辅助经鼻正压通气(nPAP)治疗肺性脑病的临床疗效及其对患者神经功能的影响。方法选取2012年1月—2015年10月北海市中医医院收治的肺性脑病患者104例,随机分为对照组与观察组,每组52例。对照组患者予以基础治疗和n PAP治疗,观察组患者在对照组基础上予以醒脑静注射液辅助治疗;两组患者均连续治疗7 d。比较两组患者临床疗效,治疗前后血气分析指标〔氧分压(PaO_2)、二氧化碳分压(PaCO_2)、血氧饱和度(SaO_2)〕和神经功能指标〔总超氧化物歧化酶(T-SOD)、丙二醛(MDA)、白介素8(IL-8)〕,治疗前和治疗后2、6、12、24 h格拉斯哥昏迷量表(GCS)评分。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者PaO_2、PaCO_2、SaO_2比较,差异无统计学意义(P>0.05);治疗后观察组患者PaO_2、SaO_2高于对照组,PaCO_2低于对照组(P<0.05)。治疗前两组患者T-SOD、MDA、IL-8水平比较,差异无统计学意义(P>0.05);治疗后观察组患者T-SOD水平高于对照组,MDA、IL-8水平低于对照组(P<0.05)。治疗前两组患者GCS评分比较,差异无统计学意义(P>0.05);治疗后2、6、12、24 h观察组患者GCS评分高于对照组(P<0.05)。结论醒脑静注射液辅助n PAP治疗肺性脑病的临床疗效确切,可有效改善患者血气分析指标及神经功能。

Objective To analyze the clinical effect and impact on neurological function of xingnaojing injection in the adjuvant therapy for pulmonary encephalopathy patients undergoing nasal positive airway pressure ventilation. Methods A total of 104 patients with pulmonary eneephalopathy were selected in the Traditional Chinese Medicine Hospital of Beihai from January 2012 to October 2015, and they were randomly divided into control group and observation group, each of 52 cases. Patients of control group received basic treatment and nasal positive airway pressure ventilation, while patients of observation group received extra xingnaojing injection as adjuvant therapy; both groups continuously treated for 7 days. Clinical effect, blood -gas analysis index （ including PaO2, PaCO2 and SaO2 ） and index of neurological function （ including T-SOD, MDA and IL-8 ） before and after treatment, GCS score before treatment, after 2 hours, 6 hours, 12 hours and 24 hours of treatment were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group （P 〈0. 05）. No statistically significant differences of PaO2 , PaCO2 or SaO2 was found between the two groups before treatment （P 〉 0. 05 ） ; after treatment, PaO2 and SaO2 of observation group were statistically significantly higher than those of control group, while PaCO2 of observation group was statistically significantly lower than that of control group （ P 〈 0. 05 ）. No statistically significant differences of T-SOD, MDA or IL-8 was found between the two groups before treatment （ P 〉 0. 05 ） ; after treatment, T-SOD of observation group was statistically significantly higher than that of control group, while MDA and IL-8 of observation group were statistically significantly lower than those of control group （ P 〈 0. 05 ）. No statistically significant differences of GCS score was found between the two groups before treatment （ P 〉 0. 05 ） , while GCS score of observation group was statistically significantly higher than that of control group after 2 hours, 6 hours, 12 hours and 24 hours of treatment, respectively （P 〈 0. 05 ）. Conclusion Xingnaojing injection has certain clinical effect in the adjuvant therapy for pulmonary encephalopathy patients undergoing nasal positive airway pressure ventilation, can effectively adjust the blood - gas analysis index and improve the neurological function.