肺癌患者中血清胰岛素样生长因子1受体和S100A2的表达及其临床意义

Expression and Clinical Significance of Serum Levels of IGF-1R and S100A2 in Patients with Lung Cancer

目的探讨肺癌患者中血清胰岛素样生长因子1受体(IGF-1R)和S100A2的表达及与其临床病理因素间的相关性。方法选择肺癌患者共34例;同期纳入健康体检者40例为对照组,应用酶联免疫吸附(Elisa)法测定两组血清IGF-1R和S100A2水平。所有患者随访2年,记录死亡患者例数,比较死亡患者与存活患者的血清IGF-1R和S100A2水平。结果与对照组比较,肺癌组血清IGF-1R水平明显升高,而S100A2水平明显降低,差异均有统计学意义(P<0.01);血清IGF-1R和S100A2表达水平与肺癌患者的性别、年龄及病理类型无明显相关性(P>0.05),而与肿瘤分化程度、TNM分期及淋巴结转移显著相关(P<0.01);随访2年发现:19例死亡,15例存活;死亡患者入院时血清IGF-1R水平明显高于存活者,而S100A2水平明显低于存活者,差异有统计学意义(P<0.01)。结论肺癌患者血清IGF-1R和S100A2表达异常,且与肺癌的恶性程度密切相关,对评价临床预后具有重要临床价值。

Objective To investigate the serum expression of IGF-1R and S100A2 in patients with lung cancer and the correlation with clinicopathological parameters. Methods 34 cases with lung cancer were collected. At the same time,40 healthy cases was selected as the control group. Elisa method was used to detect serum levels of IGF-1R and S100A2 in both groups. IGF- 1R and S100A2 levels were compared between both groups. 2-year follow-up was conducted tO both groups, death cases were re- corded ,and serum levels of IGF-1R and S100A2 in both groups were compared. Results Serum levels of IGF-1R of lung cancer were obviously higher than the control group, and S100A2 obviously decreased（P 〈 0.01 ）. Serum levels of IGF-1R and S100A2 had no significant correlation with age ; gender, and pathological type （ P 〉 0.05 ）, and significant correlated with differentiation, TNM stage, and lymph node metastasis, there had statistical difference （P 〈 0.01 ）. After 2-year followed up, 19 cases were dead and 15 survived. Serum level of IGF-1R in death group was obviously higher than survival group, and S100A2 was remarkably lower, there had statistical difference （P 〈 0.01 ）. Conclusion Serum levels of IGF-1R of lung cancer obviously increased, while S100A2 level is low, which is closely related with grade malignancy, and has important clinical value in evaluating prognosis.