不同麻醉方式对肠癌患者免疫功能的影响

Influence of Different Anesthesia Methods on Immune Function of Patients with Colorectal Cancer

目的探讨不同麻醉方式对大肠癌患者免疫功能的影响。方法将78例大肠癌患者随机分为A、B组,各39例。A组给予腰硬联合麻醉,B组给予丙泊酚联合瑞芬太尼靶控输注麻醉。比较2组患者手术前后的免疫状态。结果 A组麻醉后及术后各时段的CD_3、CD_4、CD_8、CD_4/CD_8及NK的表达水平均明显高于B组(P<0.05)。结论腰硬联合麻醉和靶控输注静脉麻醉均能抑制大肠癌手术患者的免疫功能,其中腰硬联合麻醉的抑制作用相对较弱。

Objective To explore the influence of different anesthesia methods on the immune function of patients with colorectal cancer. Methods 78 cases of colorectal cancer patients were randomly divided into group A and B,39 cases in each. Group A was given combined spinal epidural anesthesia, Group B was given propofol combined target control infusion fentanyl anesthesia. Immune status before and after surgery of the 2 groups were compared. Results In each period of group A after anes- thesia and postoperative of CD3 , CD4, CDs and CD4/CD8 and NK expression levels were significantly higher than those of group B （P 〈0. 05 ）. Conclusion Combined spinal epidural anesthesiaand target controlled infusion intravenous anesthesia can inhibit the immune function in patients with colorectal cancer, and combined spinal epidural anesthesia inhibitory effect is relatively weak.