喜炎平注射液治疗手足口病联合用药方案的真实世界研究

Real world analysis to explore Xiyanping injection combined with other drugs for hand-foot-mouth disease

该文应用整体网分析的方法,针对喜炎平注射液治疗手足口病的3 204例登记注册式研究数据,分析了其联合用药方案,发现喜炎平注射液的联合用药方案与《手足口病诊疗指南》一致性较好,但存在一些值得注意的问题:一是抗生素应用比例过大,超过预防继发感染的需要;二是利巴韦林的应用意义不大。该文认为从喜炎平注射液治疗手足口病的临床联合用药方案来看,其抗菌和抗病毒的临床价值尚未被充分认识。

Integrated network analysis was used in this paper to analyze Xiyanping injection combined therapy for hand-foot-mouth disease based on the registered research data of 3 204 cases. It was found that the drug combination therapy was almost consistent with the guidelines for the diagnosis and treatment of hand foot mouth disease, but there were some problems to be noticed： there were too many applications of antibiotics, more than the need in preventing secondary infection ; and ribavirin was not necessary for use. This ar- ticle showed that the clinical antibacterial and antiviral values of Xiyanping injection has not been well recognized for hand-foot-mouth disease.