摘要
利用各种色谱技术对山茱萸的化学成分进行研究,从山茱萸水提取物中分离得到6个化合物,分别为6'-O-乙酰基-7α-O-乙基莫诺苷(1),(-)-isolariciresinol 3α-O-β-D-glucopyranoside(2),芹菜素(3),cirsiumaldehyde(4),对香豆酸(5),咖啡酸(6),其中化合物1为新化合物,化合物2~4为首次从山茱萸属植物中分离得到。利用MTT法检测了化合物2~6对缺氧缺糖损伤的PC12细胞的保护作用,结果表明化合物4在1.0μmol·L-1的浓度下,对OGD/R损伤的PC12细胞物有一定的保护作用。
To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), ( - )-isolariciresinol 3α-O-β-D-glucopyranoside (2), apigenin (3) , cirsiumaldehyde(4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside, and compounds 2-4 were obtained from the Comus genus for the first time. Compounds 2-6 were evaluated for the viability of PC12 cells when exposedin conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/ R treated PC12 cells at the concentration of 1.0 μmol · L^-1.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第24期4605-4609,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81473119
81473590
81402814
81274115)
中日友好医院青年科技英才项目(2014-QNYC-B-10)