C反应蛋白和红细胞分布宽度联合早期诊断慢性阻塞性肺疾病的价值

Research of diagnosing chronic obstructive pulmonary disease by combining C-reactive protein and Red blood cell distribution width

目的:探讨C-反应蛋白(CRP)和红细胞分布宽度(RDW)对慢性阻塞性肺疾病(COPD)的联合诊断价值,为COPD的早期诊断发掘新的标志物和诊断模式。方法:采集COPD(139例)和健康体检者(139例)的静脉血,检测CRP和RDW值,用单因素方差(one-way ANOVA)比较COPD和健康体检者两组间CRP和RDW值的变化;随后用SPSS 19.0软件绘制CRP和RDW分别诊断COPD的受试者工作曲线(ROC曲线),计算诊断价值;然后用Logistics回归预测CRP和RDW诊断COPD的概率,最后绘制CRP和RDW联合诊断COPD的ROC曲线,计算曲线下面积(AUC)。结果:CRP单独诊断COPD的AUC为0.713,RDW单独诊断COPD的AUC为0.875,CRP和RDW联合诊断COPD的AUC为0.957,最大约登指数为0.81,敏感度和特异度分别为88%和93%。结论:CRP和RDW分别对COPD具有一定的诊断价值,二者联合可作为COPD早期诊断的新指标。

Objective To explore a new diagnostic model for chronic obstructive pulmonary disease （COPD）, we researched the diagnosing values of combining the C-reactive protein （CRP） and red blood cell distribution width （RDW）. Methods The venous blood of COPD （139） and health groups （139） for measuring CRP and RDW was colleeted, then the CRP and RDW levels were compared by one-way ANOVA and the receiver operator characteristic curve （ROC） were drew by SPSS19.0 respectively. And the combined diagnostic values were calculated by researchers. Finally, the researchers gained the combined probability ratio about CRP and RDW diagnosing COPD by logistics, and drew the summary ROC and calculated the area under curve（AUC）. Results The AUC of CRP and RDW diagnosing COPD was 0.713 and 0.875, respectively. The summary AUC and Youden＇s index （YI） of combining CRP and RDW were 0.957 and 0.81, respeetively. The sensitivity and specificity of combining CRP and RDW were 88% and 93%, respectively. Conclusion CRP and RDW could be useful biomarkers in the diagnosing of COPD, and combining CRP and RDW gets more high diagnostic values.