菊粉对肥胖人群血脂影响临床观察

Clinical Observation of the Inulin Effect on Blood Lipids in Obese People

目的:观察菊粉对肥胖人群血脂水平的影响。方法:选取2015年4月—2015年6月于甘肃省人民医院门诊就诊的肥胖人群120例,随机分为3组,分别给予服用菊粉治疗(10 g/d,1次/d,A组);常规饮食控制治疗(B组);40例不予任何处理(空白对照组,C组)观察治疗前及治疗3个月后血脂及体重、腰围、腹围的变化。结果:3组受试者均为40例,经3个月治疗,结果显示A组分别与B组及C组治疗后总胆固醇水平有显著差异(P=0.0471,P=0.038),A组分别与B组及C组治疗后甘油三酯水平有显著差异(P=0.018,P=0.018),A组分别与B组及C组治疗后高密度脂蛋白水平有显著差异(P=0.041,P=0.043),A组分别与B组及C组治疗后低密度脂蛋白水平有显著差异(P=0.041,P=0.012),以上分析在B组与C组间均无显著差异。3组患者体重及腹围、臀围等与治疗前无明显差异。结论:菊粉可以起到降低血脂的作用,但其机制尚需深入研究以明确。

Objective：Observe the effect of inulin on lipid of obese people. Methods：Obese people from clinic in Gansu province people＇s hospital during April to June 2015 were randomly divided to three group. Give them inulin-frunctans（10 mg,once a day,group A）,control diet（group B）,and non-treated（group C）respectively. Observe serum lipids and body weight,waist circumference and abdomen circumference change before and after 3 months of treatment. Results：40 cases of each group,by 3 months treatment,results displayed total cholesterol level of group A has significantly differences compared with group B and C（P=0.0471,P=0.038）,glycerol trilaurate level of group A has significantly differences compared with group B and C（P=0.018,P=0.018）,high-density lipoprotein level of group A has significantly differences compared with group B and C（P=0.041,P=0.043）,after treatment,low density lipoprotein level of group A has significantly differences compared with group B and C（P=0.041,P=0.012）,the above analysis showed no significant differences between group B and C. Body weight and waist circumference,hip circumference of 3 groups have no difference in treatment. Conclusion：Inulin can play a role in cholesterol-lowering,but the mechanism needs further studies to investigate.