战骨中一个新的黄酮苷类成分

A new flavonoid glycoside from the stem barks of Premna fulva

采用ODS、硅胶、凝胶等柱色谱方法对战骨（Premna fulva）干燥茎皮的化学成分进行分离纯化,通过NMR,MS等波谱技术鉴定化合物结构,分离鉴定了9个化合物,分别为：（2R）-naringenin-5-O-β-D-xylopyranosyl（1→6）-β-D-glucop-yranoside（1）,芹菜素（2）,（2S）-柚皮素-7-O-β-D-葡萄糖苷（3）,（2S）-helichrysin（4）,芹菜素-6-C-α-L-阿拉伯糖-8-C-β-D-木糖苷（5）,vicenin 2（6）,芹菜素6-C-β-D-葡萄糖-8-C-β-D-木糖苷（7）,芹菜素6-C-β-D-木糖-8-C-β-D-葡萄糖苷（8）,vitexin（9）。其中化合物1为新黄酮苷,化合物3-5,7-9均为首次从该植物中分离得到。初步评价了化合物1-9对LPS刺激的RAW 264.7巨噬细胞的NO产生的抑制作用,化合物2,6-9具有中等的抗炎活性。

A new flavonoid glycoside, named（2R）-naringenin-5-O-β-D- xylopyranosyl（1→6）-β-D-glucopyranoside（1）, together with other eight known compounds（2-9）, was isolated and characterized. Compounds 3-5, 7-9 were isolated from the stem barks of Premna fulva for the first time. The anti-inflammatory activities of all the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide（NO）production in RAW 264. 7 macrophages cells. Compounds 2, 6-9 exhibited moderate anti-inflammatory activities.