基于丝网印刷的花状CuO和CuO-MWCNTs修饰银插指电极的非酶葡萄糖传感器

Nonenzymatic glucose biosensor based on screen-printed flower-like CuO and CuO-MWCNTs modified silver interdigitated electrodes

通过实验制得纳米CuO片和CuO-MWCNTs复合物,通过丝网印刷的方式印制在银插值电极上,制得两种非酶葡萄糖传感器。CuO和CuOM WCNTs通过SEM,TEM和XRD进行表征。通过循环伏安法（CV）和计时电流法（I-t）得出CuO-MWCNTs修饰的电极比CuO修饰的电极对葡萄糖表现出更高的电化学活性,并且具备高灵敏度（1211A mmol/L·cm-2）,快速响应时间（3s）,低检出限（3 nmol/L）和宽线性区间（4-11.5 mmol/L）等优点。制得的传感器能够有效的抵抗尿酸（UA）、多巴胺（DA）、抗坏血酸（AA）、Na Cl、果糖、麦芽糖等物质的干扰。通过人体血清样本的检测,该传感器能够适用于实际应用中血糖的检测。

Two non - enzymatic glucose sensors based on ordered self - assembly of screen - printed flower - like CuO and CuO- MWCNTs modified silver interdigitated electrodes have been successfully fabricated by a facile and effective method. The prepared flower- like CuO and CuO -MWCNTs were characterized by scanning electron microscopy （ SEM）, transmission electron microscopy （ TEM ） and X - ray diffraction （ XRD ）. The cyclic voltammetry （CV） and chronoamperometry demonstrated that the CuO -WMCNTs modified electrode displayed much higher electrocatalytic activity than that of the CuO modified electrode toward glucose, exhibiting a high sensitivity of 1211A mmol/L - cm2, a fast response time of 3s, a low detection limit of 3 nmol/L （ S/N = 3） and wide linear range from 4 ixmol/L to 11.5 mmol/L. The sensors can effectively resist the effect of interferents such as UA, DA, AA, fructose, actose, sucrose and NaCI. In addition, the results tested by real blood serum samples showed that the proposed modified electrode wasapplicable and acceptable for determination of glucose in real blood serum samples. Thus, the CuO and CuO - MWCNTs modified electrodes, both of them are a potential candidate for routine Glc analysis.