期刊文献+

某院外科感染常见病原菌分布及耐药性分析 被引量:4

Distribution and Drug Resistance of Common Pathogenic Bacteria in Surgical Infection
原文传递
导出
摘要 目的了解医院外科感染常见病原菌的分布及其耐药性,为外科院内感染合理选用抗生素提供参考。方法收集山东省医学科学院第三附属医院外科2013-08/2015-08住院且发生感染的患者210例,分离培养并鉴定细菌,采用K-B纸片法进行药敏试验,对病原菌的来源、分布及耐药情况进行进行统计分析。结果在210例患者中发生医院感染32例,感染率为15.23%;共检测出病原菌65株,以革兰阴性菌为主,占58.46%(38/65),其中大肠埃希菌(占27.69%)居多,其次为铜绿假单胞菌(占9.23%),肺炎克雷伯菌(占6.15%);检测出革兰阳性菌23株(占35.38%),其中以金黄色葡萄球菌为多(占16.92%),其余依次为表皮葡萄球菌、肠球菌及溶血性链球菌;产ESBLs酶大肠埃希菌、铜绿假单胞菌和检出率肺炎克雷伯菌分别为55.56%、50.00%和40.00%,未发现产ESBLs株对亚胺培南的耐药株;耐甲氧西林金黄色葡萄球菌检出率为45.45%,但对万古霉素和呋喃妥因的敏感率为100.00%。真菌4例,占6.15%,以白色念珠菌为主。结论山东医科院第三附院外科感染及多重耐药情况较严重,以革兰阴性菌为主,对亚胺培南敏感。 Objective To investigate the distribution and drug resistance of common pathogenic bacteria for in- fection in the surgical department of the hospital and provide reference for rational use of antibiotics against nosocornial infection. Methods Included into the study were 210 patients who were hospitalized in the Department of Surgery of the Third Affiliated Hospital of Shandong Academy of Medical Sciences and experienced in- fection during the period from August 2013 to August 2015. Bacteria were isolated and identified, and drug sensitivity test was performed by K - B disc method. Sources, distribution and drug resistance of pathogenic bacteria were statistically analyzed. Results Among the 210 patients, nosocomial infection occurred in 32 (15.23%) ; 65 isolates were obtained, and gram -negative bacteria accounted for 58.46% (38/65), among which E. coli accounted for the most (27. 69% ), followed by Pseudomonas aeruginosa (9. 23% ) and Kleb- siella pneumoniae (35.38%). Twenty three (35.38%) gram -positive isolates were obtained, among which Staphylococcus aureus accounted for the most (16.92%), followed by Staphylococcus epiderrnidis, entero- cocci and Streptococcus hemolytieus. The detection rates of ESBLs - producing E. coli, Pseudomonas aerugi- nosa and Klebsiella pneumoniae were55.56% , 50% and 40% , respectively. No imipenem - resistant ESBLs - producing strain was found. The detection rate of methicillin resistant Staphylococcus aureus was 45.45 % , while 100. 00% were sensitive to vancomycin and nitrofurantoin. Fungi were found in 4 (6. 15% ) patients, with Canidida albicans accounting for the majority. Conclusion Infection and multidrug resistance are serious in the surgical department of the hospital. Gram - negative bacteria account for the majority and are sensitive to imipenem.
出处 《寄生虫病与感染性疾病》 CAS 2016年第4期234-239,共6页 Parasitoses and Infectious Diseases
关键词 外科 医院感染 病原菌分布 耐药性 surgery nosocomial infection pathogen distribution drug resistance
  • 相关文献

参考文献7

二级参考文献72

  • 1周彦娇,张鹏,吴尚为.医院感染的病原体及耐药现状[J].中华医院感染学杂志,2005,15(11):1317-1320. 被引量:32
  • 2徐小平,高霞,池晓霞,盖俊惠,艾辉,李卓成.葡萄球菌属和肠球菌属耐药性监测研究[J].中华医院感染学杂志,2006,16(3):324-327. 被引量:70
  • 3任南,吴安华,冯丽,文细毛,易霞云,吕一欣,龚瑞娥,黄勋,王曼平.住院患者抗菌药物临床应用横断面调查[J].中华医院感染学杂志,2006,16(9):1048-1050. 被引量:209
  • 4吴敏,邓建平,姚春红,朱海波.318株革兰阳性球菌体外耐药监测分析[J].中华医院感染学杂志,2007,17(3):328-330. 被引量:7
  • 5余方友,李美兰,张雪青,陈占国,陈增强,周铁丽.携带Panton-Valentine杀白细胞素基因金黄色葡萄球菌所致感染类型研究[J].中华检验医学杂志,2007,30(5):568-571. 被引量:17
  • 6Mammeri H,Poirel L,Mangeney N,Nordmann P.Chromosomal integration of a cephalosporinase gene from Acinetobacter baumannii into Oligella urethralis as a source of acquired resistance to β-lactams.Antimicrob Agents Chemother 2003; 47:1536-1542.
  • 7Wisplinghoff H,Edmond MB,Pfaller MA,Jones RN,Wenzel RP,Seifert H.Nosocomial bloodstream infections caused by Acinetobacter species in United States hospitals:clinical features,molecular epidemiology and antimicrobial susceptibility.Clin Infect Dis 2000; 31:690-697.
  • 8Koeleman JG,Parlevliet GA,Dijkshoorn L,Savelkoul PH,Vandenbroucke-Grauls CM.Nosocomial outbreak of multi-resistant Acinetobacter baumannii on a surgical ward:epidemiology and risk factors for acquisition.J Hosp Infect 1997; 37:113-123.
  • 9Vahaboglu H,Ozturk R,Aygun G,Coskunkan F,Yaman A,Kaygusuz A,et al.Widespread detection of PER-1-type extended-spectrum beta-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey:a nationwide multicenter study.Antimicro Agents Chemother 1997; 41:2265-2269.
  • 10Marilyn CR.Multidrug-resistant genes are associated with an 86-kb island in Acinetobacter baumannii.Trends Microbiol 2006; 14:375-378.

共引文献598

同被引文献47

引证文献4

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部