不同血尿酸水平与非酒精性脂肪肝的相关性研究

Correlation between different levels of serum uric acid and nonalcoholic fatty liver disease

目的探讨不同血尿酸(SUA)水平与非酒精性脂肪肝(NAFLD)的相关性。方法选取2011-2012年度于本院参加健康体检的7 893例作为研究对象,进行统一问卷调查、血液生化及肝脏超声检查。依据基线SUA水平将研究对象四分位分组,比较4组间NAFLD检出率,并对NAFLD的影响因素进行多因素logistic回归分析。结果随着SUA水平的升高,NAFLD的检出率逐渐升高,四组NAFLD检出率分别为29.5%、42.5%、50.5%和63.9%。影响发生NAFLD的多因素logistic回归分析显示:校正了年龄、性别等因素后,与第一分位组比较,第二、三、四分位组发生NAFLD的OR值分别是1.218(95%CI:1.033~1.437)、1.353(95%CI:1.139~1.607)、1.713(95%CI:1.428~2.053)倍(P<0.05)。结论SUA水平升高是发生NAFLD的独立危险因素,与NAFLD的发病密切相关。

Objective To explore the relationship between different levels of serum uric acid （SUA） and nonalcoholic fatty liver disease （NAFLD）. Methods A total of 7,893 staff members who participated in health check-up in Kailuan General Hospital from 2011 to 2012 were selected as the research subjects. Unified questionnaire surveys, serum biochemical tests and liver ultrasound examination were performed. According to the baseline SUA measurement, the subjects were divided into 4 groups（ first, second, third and forth quartile groups ）. The detection rates of NAFLD in various SUA groups were compared. Multiple logistic regression analysis was used to analyze the influencing factors of NAFLD. Results The detection rates of NAFLD of the 4 quartile groups were progressively increased along with the increasing level of SUA, being 29.5%, 42.5%, 50.5% and 63.9% respectively. Multiple logistic regression analysis showed that after adjusting for age, gender and other risk factors, the risk of developing NAFLD in the second, third and fourth quartile groups separately increased by 1.218 （ 95%CI： 1.033-1.437）, 1.353（95%CI： 1. 139-1.607） and 1.713（95%Cl：1.428-2.053）times as compared with that of the first quartile group（P〈0.05）. Conclusions The increased SUA level is an independent risk factor for NAFLD, and it is closely related to the incidnece of NAFLD.