乙醛与三氟甲基酮的Aldol反应研究

Study of the Aldol Reactions of Acetaldehyde with Trifluoromethyl Ketones

文章考察了溶剂、反应浓度以及酸的种类和用量对反应的影响。然后,实现了乙醛与不同结构三氟甲基不饱和酮的Aldol反应,得到的Aldol产物经过双氧水氧化,以最高92%的产率得到相应的稳定的羧酸。

In the paper, the effects of solvent, concentration and the type and amount of acid on the reaction were investigated. Then, aldol reactions of the different structure of trifluoromethyl unsaturated ketones with acetaldehyde. Aldol products are oxidized by hydrogen peroxide, affording corresponding stable carboxylic acid in high yields（up to 92 % yield）.