肥大细胞在多发性硬化中的发病机制研究进展

Progress of Mast cells in the Pathogenesis of Multiple Sclerosis

多发性硬化（MS）是最常见的中枢神经系统炎性脱髓鞘疾病之一.实验性自身免疫性脑脊髓炎（EAE）模型和MS具有相似的病理生理过程,是MS研究的经典模型.目前认为,MS的发病与遗传、环境及患者机体自身免疫状态等多因素有关.肥大细胞可以分泌多种炎症介质和细胞因子而发挥重要的免疫防御作用.研究表明,肥大细胞参与并调控了MS和EAE进展中的多个阶段,但机制尚未完全阐明.因此,研究肥大细胞在MS中的发病机制具有重要意义.

Multiple sclerosis （MS） is one of the most common inflammatory demyelinating diseases of the central nervous system.Experimental autoimmune encephalomyelitis （EAE） model,which has similar pathophysiological process to MS,is a classical model of MS.Recent studies demonstrated that the inducing factor of MS includes genetic predisposition,environment,as well as the immune status of patients.Mast cells could secrete a variety of cytokines and inflammatory mediators,which play an important role in immune defense.Emerging evidence indicated that MCs are involved in the regulation of MS and EAE in several stages,but the mechanisms have not been fully clarified.Therefore,study the pathogenesis mechanisms of MCs in MS is very important.