白细胞介素-20、白细胞介素-22研究进展被引量：1

Research progress of interleukin-20 and interleukin-22

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摘要白细胞介素（IL）-20、IL-22属于IL-20亚家族细胞因子,IL-20亚家族细胞因子与IL-10一同属于IL-10家族.IL-20亚家族细胞因子在结构、功能、作用的受体复合物及靶细胞上具有相似性.与IL-10家族其它成员是抑炎性因子不同,IL-20是促炎性因子,且主要在炎症早期发挥作用.IL-22在不同疾病中表现出促炎或抑炎的不同作用,其在维持黏膜屏障功能及组织内稳态中发挥了重要作用.因而研究IL-20、IL-22的细胞来源、作用的靶细胞、表达调节以及作用机制可能会使IL-20和IL-22成为治疗疾病的靶点. Interleukin （IL）-20,Interleukin （IL）-22 belong to the IL-20 subfamily of cytokines,IL-20 subfamily of cytokines and IL-10 together belong to the IL-10 family.IL-20 subfamily cytokines are similar in structure,biological functions,receptor complex and target cell profiles.Different from other members of the IL-l0 family,IL-20 is a pro-inflammatory factor,and it plays a role in the early stage of inflammation.The different effects of IL-22 in different diseases showed different effects of promoting inflammation or inhibiting inflammation,which played an important role in the maintenance of mucosal barrier function and tissue homeostasis,IL-22,IL-20 may become a target for treatment of disease.

作者牛慧慧柴向斌

机构地区山西医科大学第一医院耳鼻咽喉头颈外科

出处《国际免疫学杂志》 CAS 2016年第6期629-634,共6页 International Journal of Immunology

关键词白细胞介素20 白细胞介素22 Interleukin-20 Interleukin-22

分类号 R758.63 [医药卫生—皮肤病学与性病学]

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