注射用兰索拉唑对健康者胃内24小时pH值影响的研究

The effect of lansoprazole injection on 24-hour intragastric pH in healthy volunteers

目的研究注射用兰索拉唑对健康受试者胃内24 h pH值的影响。 方法选择健康志愿者20例，男女各10例，按随机数字表法分为试验组和对照组，每组10例。pH值测定电极入胃测定胃内pH基础值后立即静脉给药，试验组静脉滴注兰索拉唑30 mg，对照组静脉滴注等量0.9%氯化钠溶液，然后测定胃内24 h pH值。 结果试验组静脉给药结束后胃内pH值开始出现明显升高（P〈0.05）。给药结束至24 h，试验组胃内pH值均高于对照组，尤其是给药后前12 h内，试验组与对照组胃内pH值比较差异有统计学意义（P〈0.01）。试验组静脉滴注兰索拉唑后24 h胃内pH值为4.565 ± 1.109，对照组为2.211 ± 0.263，两组比较差异有统计学意义（P〈0.01）；试验组pH值〉4.0总时间百分比为（73.36 ± 21.08）%；pH值〉6.0总时间百分比为（53.22 ± 23.76）%，与对照组的（13.28 ± 10.55）%、（3.92 ± 2.17）%比较，差异均有统计学意义（P〈0.01）。 结论注射用兰索拉唑的抑酸强度是值得肯定的，且每12小时给药1次在消化性溃疡合并出血的治疗中可充分发挥作用。

Objective To investigate the effect of lansoprazole injection on 24-hour intragastric pH in healthy volunteers. Methods The volunteers inclouding 10 women and 10 men, were divided into experitmental group and control group randomly, each group of 10 cases. After testing the pH initial value in stomach through pH determination electrode, the cases in experitmental group were drip the drug of lansoprazole injection, the cases in control group were drip the same volume of 0.9% sodium chloride solution. Then constantly determined the value of pH in the stomach for 24 h. Results The pH value in the stomach of expertimental group after injected lansoprazole was significantly higher than that before administration （P 〈 0.05）. The pH value in the stomach of expertimental group was higher than that in control group between finished of injection and 24 h, especially in the first 12 h after administration, there were significantly differences （P 〈 0.01）. The pH value in experimental group after injected lansoprazole for 24 h was 4.565 ± 1.109, in control group was 2.211±0.263, there was significant difference （P 〈 0.01）. The percentage of maintenance time of pH reaching 4.0 and 6.0 in stomach in experimental group were （73.36 ± 21.08）% and （53.22±23.76）%, in control group were （13.28 ± 10.55）% and （3.92 ±2.17）%, there were significant differences （P 〈 0.01）. Conclusions The strength of acid suppresion of lansoprazole injection is worthy of approving, and it can work at full capacity in treatment of patients with peptic ulcer complicated with upper gastrointestinal hemorrhage if lansoprazole is given every 12 h.