新生儿高胆红素血症远期神经心理发育的相关研究

Relatedresearch about neonatal hyperbilirubinemia on long-term neuropsychological development

目的评估新生儿期高胆红素血症是否造成儿童远期神经心理发育影响。方法分别对67例黄疸组和58例对照组进行发育商、气质类型、社会生活能力测试,随访远期神经发育情况。结果黄疸组患儿的发育商为(92.090±5.279)分,与对照组(93.830±8.816)分相比,差异无统计学意义。黄疸组气质类型为D型者19例(28.36%),为E型者48例;对照组气质类型为D型者13例(22.41%),为E型者45例;两组比较差异无统计学意义。黄疸组社会生活能力有问题发生率为2.98%(2/67),对照组有问题发生率为1.72%(1/58),两组比较差异无统计学意义。结论经早期治疗的新生儿期高胆红素血症对婴儿远期发育商、气质、社会生活能力等神经心理发育无明显影响,因此需早期干预新生儿高胆红素血症,对改善远期预后有非常重要的临床意义。

Objective To evaluate whether neonatal hyperbilirubinemia has effect on children＇s long-term neuropsychological development. Methods 67 cases of neonatal hyperbilirubinemia group and 58 cases of control group were surveyed about intelligence, temperament and social-life abilities tests, and long-term follow-up of neurodevelopmental was carried out. Results The intelligence development of neonatal hyperbilirubinemia group was （92.09±5.279）. Compared with the control group （93.83±8.816）, there was no statistically significant difference （P=0.193）. The type D of temperament types in neonatal hyperbilirubinemia group was 19 cases （28.36%）, and type E was 48 cases;type D in control group was 13 cases （22.41%）, and type E was 45 cases. There was no signifi-cant difference between the two groups. The incidence rate of hyperbilirubinemia group which had social life ability problem was 2.98%（2/67）, and the control group was 1.72% （1/58）. There was no significant difference between the two groups （P〉0.05）. Conclusion After early treatment of neonatal hyperbilirubinemia, there is no significant effect on neuropsychological development on important as-pects of long-term development of intelligence and temperament and social-life abilities. Therefore, early clinical intervention is veryimportant to improve long-term prognosis on neonatal hyperbilirubinemia.