快速康复外科理念联合超前镇痛对结肠癌患者的干预效果分析

Analysis of the concept of rapid rehabilitation surgery combined with preemptive analgesia effect of intervention on patients with colon cancer

目的探讨快速康复外科理念联合超前镇痛对结肠癌患者的干预效果及临床意义。方法选择接受结肠癌根治术患者78例,随机分为对照组及观察组,分别有39例,对照组仅接受常规镇痛及围手术期处理,观察组在此基础上接受快速康复外科及超前镇痛干预,对术前及术后Prince-Henry评分、Bruggrmaann comfort scale评分、细胞因子水平进行测定。结果观察组Prince-Henry评分、Bruggrmaann comfort scale评分术后24、48、72h较对照组同期均存在显著性差异(P<0.05),观察组患者术后24hIL-8、TNF-α较对照组同期有显著性下降(P<0.05)。术后48hIL-6、IL-8、TNF-α较对照组同期有显著性下降(P<0.05)。结论快速康复外科理念联合超前镇痛可缓解结肠癌根治术患者术后疼痛、提高舒适程度,且有助于降低炎性因子水平。

Objective To investigate the clinical significance and the concept of rapid rehabilitation surgery combined with preemptive analgesia effect of intervention on patients with colon cancer. Methods 78 patients of colon cancer patients were randomly divided into control group and observation group, the control group received only routine anesthesia, observation group received rapid rehabilitation surgery and preemptive analgesia on this basis, preoperative and postoperative Prince-henry, Bruggrmaann comfort scale score, cytokines levels were measured. Results Prince-henry, Bruggrmaann comfort scale score of observation group after 24 h, 48 h, 72 h compared with the same period in the control group showed significant differences （P 〈0.05）, IL-8, TNF-αof patients in the observation group at 24 h over the same period compared with the control group significantly decreased （P〈0.05）,after 48 h IL-6,IL-8,TNF-αsignificantly decreased （P〈0.05）. Conclusions Perioperative multi-mode analgesia and fast track surgery help relieve pain after radical colon cancer surgery patients, and help relieve stress and inflammatory cytokines.