调节性T细胞在肝癌患者中的预后意义（英文）

Prognostic significance of regulatory T lymphocytes in patients with hepatocellular carcinoma

目的:通过系统性文献检索和meta分析评估调节性T细胞与肝癌患者生存时间的相关性。创新点:针对调节性T细胞在肝癌患者中的预后意义进行系统性文献综述和分析,进一步证实其可以作为预测肝癌预后的指标。方法:在MEDLINE和Embase数据库中搜索相关文献,提取数据并对文献质量进行评估。有18项研究纳入到最后的分析,包括的肝癌患者多数为乙肝病毒感染。利用meta分析的方法对相关结果进行合并分析。结论:本实验证实,肿瘤组织内调节性T细胞与肝癌患者预后显著相关,调节性T细胞数量高的患者生存时间和无瘤生存期均较短。同样,外周循环调节性T细胞数量与肝癌患者生存期也呈负相关。

We investigated the prognostic role of regulatory T cells（Tregs） in patients with hepatocellular carcinoma（HCC）. Relevant evidence regarding prognostic significance of Tregs was systematically searched in MEDLINE and Embase databases. A meta-analysis was performed to compare survival in patients with high or low Tregs level（either in peripheral blood or tumor）. Eighteen studies were identified that fulfilled for the eligibility criteria and were included for data synthesis. Our pooled hazard ratios（HRs） demonstrated that increased Tregs intratumoral accumulation was significantly associated with worse overall survival（HR=2.04, 95% confidence interval（CI）： 1.72–2.42） and diseasefree survival（HR=1.82, 95% CI： 1.58–2.09）. Three studies evaluated the role of Tregs in peripheral blood, and all of them showed that increased peripheral Tregs correlated with shortened disease-free and overall survival. Collectively, our results showed that the increased Tregs count is tightly associated with the shortened survivals. Its measurement in either primary tumor or even circulation might be a candidate marker of prognostic significance in HCC patients.