TNF-α和IL-6在鼻咽血管纤维瘤中的表达及意义

Expression and significance of tumor necrosis factor-alpha and interleukin-6 in juvenile nasopharyngeal angiofibroma

目的:检测肿瘤坏死因子α(TNF-α)和白细胞介素-6(IL-6)在鼻咽血管纤维瘤(JNA)中的表达水平,并探讨TNF-α和IL-6在JNA骨质破坏机制中的作用。方法:应用免疫组织化学法检测TNF-α和IL-6在20例JNA患者和10例正常下鼻甲组织中的表达。结果:TNF-α和IL-6蛋白在JNA中的阳性表达率均为90.0%,明显高于TNF-α和IL-6蛋白在下鼻甲组织中的阳性表达率(均为20.0%)(均P<0.01)。TNF-α和IL-6蛋白的表达与JNA临床分期无关(均P>0.05)。结论:TNF-α和IL-6在JNA组织中表达增高,可能是参与JNA骨质破坏的影响因素。

Objective： To detect the expression of tumor necrosis factor-alpha （TNF-α） and interleukin-6 （IL-6） in nasopharyngeal angiofibroma （JNA） and to explore the role of TNF-α and IL-6 in the mechnism of the bone destruction in JNA. Methods： The expressions of TNF-α and IL-6 in JNA tissue of 20 patients and normal inferior turbinate tissues in 10 cases of persons were determined by SP method of immunohistochemistry. Re- sults： The positive expression rates of TNF-αand IL-6 proteins in JNA both were 90.0%, significantly higher than those in inferior turbinate tissues which both were 20.0% （P〈0.01）. The expressions of TNF-α and IL-6 pro- tein were no correlation with the clinical stage of JNA （P〉0.05）. Conclusion： The higher expressions of TNF-α and IL-6 in JNA tissues may be the influence factors involved in bone destruction of the JNA.