摘要
为降低近红外脑功能漫射光断层成像(DOT)固有的逆问题病态性,并避免多模态方法的图像配准等问题,提出了基于光学自导引提供先验功能信息的脑功能DOT方法(OT-DOT),并发展了图像重构方法.模拟验证表明:上皮厚度(TLT)已知时,OT-DOT获得的重构量化度(QR)约为传统DOT的4.2倍;当TLT的估计误差小于±10%时,OT-DOT重构的QR值可达92%以上,远远优于传统DOT;噪声鲁棒性测试表明,OT-DOT与传统DOT的噪声鲁棒性相近.利用连续光DOT测量系统的仿体实验重构结果表明,所发展的OT-DOT算法获得的重构结果优于传统DOT算法.
The image reconstruction of diffuse optical tomography (DOT) for near-infrared brain functional imaging is a severely ill-posed inverse problem. Different from the widely adopted multi-mode imaging method for providing anatomical-prior to DOT, this paper proposed an optical self-guiding scheme, called OT-DOT, and the corresponding image reconstruciton algorithm is developed. The numerical and phantom validations are performed for the proposed method. Numerical reconstruction results indicate that quantitativeness ratio (QR) reconstructed with OT-DOT for the target is about 4.2 times bigger than that with traditional DOT for the known top layer thickness(TLT). QR from OT-DOT can be more 92% when the estimation error of TLT is less than ± 10%. The noise-robustness testing indicates the reconstruction ability of OT-DOT and traditional DOT are roughly the same. Phantom experiments performed using a continuous-wave DOT system show that the reconstructed results with the proposed method is better than those with traditional DOT.
作者
赵会娟
戚彩霞
刘明
秦转萍
张耀
张丽敏
李娇
周仲兴
高峰
ZHAO Hui-juan QI Cai-xia LIU Ming QIN Zhuan-ping ZHANG Yao ZHANG Li-min LI Jiao ZHOU Zhong-xing GAO Feng(College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China Tianjin Key Lab of Information Sensing ~Intelligent Control, Tianjin 300222, China)
出处
《光子学报》
EI
CAS
CSCD
北大核心
2016年第11期1-9,共9页
Acta Photonica Sinica
基金
国家自然科学基金(Nos.81371602
61475115
61475116
81401453
61575140
81571723
81671728)
天津市自然科学基金(Nos.14JCQNJC14400
15JCZDJC31800
15JCQNJC14500
16JCZDJC31200)
天津职业技术师范大学校科研发展基金(No.KYQD14007)资助~~
关键词
光谱学
生物医学光子学
光学自导引漫射光断层成像
脑功能
近红外
先验信息
图像重构方法
Spectroscopy
Biomedical photonics
Optical self-guiding diffuse optical tomography
Brainfunctional imaging
Near infrared
Prior information
Image reconstruction method