依达拉奉联合多巴丝肼片治疗血管性帕金森综合征疗效研究

Efficacy observation of levodopa and benserazide hydrochloride tablets combined with edaravone in treatment of vascular parkinsonism

目的观察多巴丝肼片联合依达拉奉治疗血管性帕金森综合征的临床疗效,以期为血管性帕金森综合征的治疗提供借鉴。方法以入榆林市星元医院就诊的血管性帕金森综合征患者为研究治疗对象,将患者随机分为观察组与对照组,对照组以多巴丝肼片治疗,观察组在对照组基础上予以依达拉奉治疗,治疗20 d,观察治疗前后临床症状与体征,采用帕金森病评定量表(UPDRS)评价临床疗效。结果共搜集患者60例,每组各30例,各组在年龄、性别、分级、UPDRS评分、危险因素等方面具有可比性。观察组患者显效17例,有效11例,无效2例,总有效率为93.33%;对照组患者显效12例,有效10例,无效8例,总有效率为73.33%。有效率比较,差异有显著性意义(P<0.05),说明观察组有效率明显高于对照组;两组患者治疗后的精神情绪行为、日常生活活动评分和运动功能评分较治疗前均有所降低(P<0.05),治疗后患者日常生活、行为精神情绪、运动检查等UPDRS评分的比较,差异有显著性(P<0.05),观察组UPDRS评分改善明显高于对照组。所有患者治疗前后一般体格检查及血、尿常规,肝肾功能,心电图均在正常范围内,未出现严重不良反应。结论依达拉奉联合多巴丝肼片治疗血管性帕金森综合征的临床疗效要优于单独使用多巴丝肼片,且具有良好的安全性。

Objective To investigate the clinical efficacy oflevodopa and benserazide hydrochloride tablets combined with edaravone in treatment of vascular parkinsonism, in order to provide the treatment reference on vascular parkinsonism. Methods The patients with vascular parkinsonism in Xingyuan Hospital of Yulin City were chosen and randomly divided into observation group and control group. The control group was given levodopa and benserazide hydrochloride tablets, the observation group was given edaravone on the base of control group. The treatment group and control group were all treated for 20 d, the clinical symptoms and signs of two groups were observed, and the clinical efficacy was evaluated by unified Parkinson＇s disease rating scale （UPDRS）. Results The age, sex, grade, UPDRS score, and risk factors of two groups had no significant difference. There were 17 cases with excellent efficacy in observation group, 11 cases effective, 2 cases valid, and the total efficacy was 93.33%, while the control group were 12 cases, 10 cases, 8 cases, and 73.33%.The effective rates of two groups had significant difference （P 〈 0.05）. Compared with before treatment, the emotional behavior score, movement function score, and daily life activities of two groups were obvious decreased （P 〈 0.05）. Compared with before treatment, the daily life, behavior, mental emotional, motion checking UPDRS score had significant difference （P 〈 0.05）. The UPDRS score of observation group was higher than the control group. The blood and urine routine, hepatic and renal function, and electrocardiogram of two groups before and after treatment were all in normal range, without serve adverse reaction. Conclusion Levodopa and benserazide hydrochloride tablets combined with edaravone in treatment of vascular parkinsonism was superior to levodopa and benserazide hydrochloride, with good safety.