酮康唑单独及联合克霉唑栓治疗老年念球菌性阴道炎的效果对比观察

Comparison of the Effect of Ketoconazole Alone and in Combination with Clotrimazole Suppositories in Treatment of Elderly Patients with Candida Vaginitis

目的:对老年念球菌性阴道炎患者应用酮康唑单独以及酮康唑联合克霉唑栓两种方法进行治疗,观察并比较疗效。方法:选择92例老年念球菌性阴道炎患者作为研究对象,随机分成研究组和参照组,给予不同的治疗方式。对参照组46例患者单独应用酮康唑治疗,对研究组46例患者应用酮康唑联合克霉唑栓进行治疗,观察并比较疗效。结果:经不同方式治疗后,对比总体有效率,研究组(95.65%)明显的优于参照组(78.26%)(P<0.05);在治疗第12周和第24周时,两组患者生命体征和症状改善评分无统计学意义(P>0.05),在治疗第4周和第8周时研究组明显优于参照组(P<0.05);对比不良反应发生率,研究组(8.69%)同参照组(10.87%)之间不具有统计学意义(P<0.05)。结论:采用酮康唑联合克霉唑栓治疗老年念球菌性阴道炎,同单纯应用酮康唑治疗相比较效果更为理想,将总体治疗有效率得到提升。

Objective： Senile candida vaginitis patients were treated with ketoconazole alone or ketoconazole combined with clotrimazole suppositories, and curative effect was observed and compared.Methods： 92 cases with candida vaginitis patients as the research object, randomly divided into study group and control group, given different treatment. The reference group in 46 cases with single application of ketoconazole therapy on the treatment of 46 cases of the study group treated with ketoconazole combined with clotrimazole suppositories, to observe and compare the efficacy of different methods.Results： After treatment, the overall efficiency was compared. The study group （95.65%） was better than the control group （78.26%） （P〈0.05）; in the treatment of twelfth weeks and twenty-fourth weeks, vital signs and symptoms score showed no significant difference （P〉0.05）; the study group was significantly better in the treatment of fourth weeks and eighth weeks control group （P〈0.05）; the ratio of adverse reaction rate of the study group （8.69%） showed no difference with the reference group （10.87%） （P〈0.05）.Conclusion： The overall treatment efficiency was improved by ketoconazole combination with clotrimazole in the treatment of elderly patients with candida vaginitis.