对比分析硫酸镁及硫酸镁联合硝苯地平治疗妊高征的临床效果

Analysis on Clinical Effect of Magnesium Sulfate and Magnesium Sulfate Combined with Nifedipine in the Treatment of Pregnancy Induced Hypertension

目的：探讨硫酸镁单独应用及与硝苯地平联合应用治疗妊娠高血压综合征（简称妊高征）的有效性。方法：2015年4月至2016年3月收治的妊高征患者92例，随机分为两组各46例，观察组应用硫酸镁（80m L/次，1-2次/d）＋硝苯地平（10m g/次，3次/d），对照组仅应用硫酸镁（80mL/次，1-2次/d）。对比两组血压水平、尿蛋白值及总有效率。结果：治疗后观察组收缩压（132.68±9.04mmHg）、舒张压（78.22±6.82mmHg）、24h尿蛋白定量（1.21±0.26g）低于对照组（142.42±10.56mmHg，86.92±7.24mmHg，1.89±0.36g）（P〈0.05）；观察组总有效率（93.48%）高于对照组（73.91%）（P〈0.05）。结论：硫酸镁与硝苯地平联合应用治疗妊高征效果优于单独用药。

Objective： To investigate the effectiveness of Magnesium Sulfate alone and combined with nifedipine in the treatment of pregnancy induced hypertension.Methods： 92 cases of pregnancy induced hypertension （PIH） from April 2015 to March 2016 were randomly divided into two groups, 46 cases in each group. Observation group application of magnesium sulfate （80ml/time, 1-2 times/D） and nifedipine （10mg/time, 3 times/D）, control group only application of magnesium sulfate （80ml/times, 1-2 times/D）. Blood pressure levels, urinary protein values and total effective rate of the two groups were compared.Results： After treatment, in observation group, systolic blood pressure （132.68 ＋ 9.04mmHg）, and the DBP （78.22 ＋ 6.82mmHg）, 24h urinary protein quantitative （1.21 ＋ 0.26 g） was lower than that of the control group （142.42 ＋ 10.56mmHg and 86.92 ＋ 7.24mmHg, 1.89 ＋ 0.36g） （P〈0.05）; in observation group, the total efficiency （93.48%） was higher than that of the control group （73.91%） （P〈0.05）.Conclusion： The application of Magnesium Sulfate and nifedipine in the treatment of pregnancy induced hypertension is better than medication alone.