血塞通注射液对呼吸衰竭机械通气患者并发应激性溃疡的影响

The effects of Xuesaitong parenteral solution on stress ulcer in the mechanical ventilation patients with respiratory failure

[目的]观察血塞通注射液对呼吸衰竭机械通气患者并发应激性溃疡的影响。[方法]78例因呼吸衰竭而气管插管机械通气患者随机分成对照组(n=42)和治疗组(n=36)。对照组给予呼吸衰竭常规治疗,治疗组在此基础上予血塞通注射液8ml稀释后静脉滴注,1次/d,疗程为7d。采用Griess法测定患者血清NO浓度;采用硫代巴比妥酸比色法测定血清MDA水平;采用黄嘌呤氧化酶法测定血清SOD浓度,并观察治疗中及治疗结束后应激性溃疡发生率。[结果]最终有71例患者完成了研究(治疗组33例,对照组38例)。治疗组患者应激性溃疡发生率为21.21%,对照组患者发生率为47.37%,治疗组发生率较对照组明显下降(P<0.05)。治疗前两患者血清NO、MDA及SOD水平均无统计学差异(P>0.05),治疗后治疗组血清MDA水平较对照组明显下降(P<0.05),而血清NO、SOD水平则明显上升(P<0.01,P<0.05)。[结论]血塞通注射液能有效降低呼吸衰竭机械通气患者应激性溃疡发生率,其可能通过抗氧化,清除氧自由基的作用。

[Objective]To investigate the effects of Xuesaitong parenteral solution on stress ulcer in the mechanical ventilation patients with respiratory failure.[Methods]Seventy-eight mechanical ventilation patients with respiratory failure were divided into 2groups at random,42 in the control group and 36 in the experimental group.Patients in the control group received respiratory failure routine treatment.Patients in the experiment group were given Xuesaitong parenteral solution in addition to routine treatment.Seven days were one treatment course.The levels of serum NO were detected by Griess method.The activity of SOD was detected by Xanthine oxidase method.The content of MDA was detected by thiobarbituricacid.The rate of stress ulcer incidence was detected after treatment.[Results]Seventy-one patients completed the study（control group =38,experiment group=33）.The rate of stress ulcer incidence was 21.21%in experiment group,which was 47.37%in control group.The incidence of stress ulcer was significantly lower in experiment group than that in the control group（P〈0.05）.There were no significant differences at the levels of serum NO,SOD and MDA before treatment between the two groups（P〉0.05）.After treatment,the levels of serum NO and SOD in experimental group were increased significantly than those in the control group（P〈0.01,P〈0.05）.The level of serum MDA was decreased significantly than that in the control group（P〈0.05）.[Conclusion]Xuesaitong parenteral solution can reduce the rate of stress ulcer incidence in mechanical ventilation due to respiratory failure.Antioxidan and scavenging oxygen free radicals may be a possible mechanism for Xuesaitong parenteral solution to treat stress ulcer.