119例联合用药含醇辅料导致双硫仑样不良反应的文献分析

Disulfiram-Like Reaction Induced by Drugs Containing Ethanol :Literature Analysis of 119 Cases

目的:分析联合用药含醇辅料导致双硫仑样不良反应的情况,为安全合理用药提供建议与参考。方法:检索2012年12月1日-2015年12月1日中国医院知识总库(CHKD)期刊全文数据库,对检索到的119例联合用药含醇辅料导致双硫仑样不良反应的中文文献进行回顾分析。结果:119例病例中,涉及含乙醇药物13种,其中以氢化可的松注射液(70例,58.83%)和藿香正气水(21例,17.65%)居多。联合用药绝大多数为抗菌药物,以头孢菌素类抗菌药物(102例,85.71%)最多。结论:建议医务人员在应用易引起双硫仑样反应的药物期间及治疗完成至少5天内尽量避免联用含醇辅料药物、使用酒精擦浴降温等,加强患者用药过程中的监护。

Objective： To provide suggestions and a reference for rational drug use in the clinic through analysis of disulfiram-like reaction induced by drugs containing ethanol. Methods： A total of 119 cases of disulfiram-like reaction induced by drugs containing ethanol reported from December 1,2012 to December 1,2015 were collected by searching Chinese Hospital Knowledge Database （CHKD）and analyzed retrospectively. Results： Thirteen kinds of drugs containing ethanol were involved in the 119 cases ,most of which were hydrocortisone injection （70 cases, 58.83%）and huoxiang zhengqi liquid（21 cases, 17.65%）. Antibacterials were mainly used in combination with other drugs, most of which were cephalosporins（ 102 cases, 85.71% ）. Conclusion： Alcohol or drugs containing ethanol should be contraindicated in patients during or within 5 d after treatment with drugs which cause disulfiram-like reaction easily.