缝隙连接与运动障碍性疾病研究进展

Research progress of relationship between gap junctions and movement disorders

缝隙连接是细胞间信号转导的重要方式。缝隙连接及其所组成的蛋白结构和(或)功能改变与多种疾病相关。运动障碍性疾病作为中枢神经系统的常见疾病,与缝隙连接有一定的关联性,其已成为国内外研究中枢神经系统疾病发病与治疗机制的关键因素。本文就缝隙连接及其与运动障碍性疾病的相关性进行概述。

Gap junctions （GJ） is an important way to transmit signals among body cells. Studies have confirmed that changes on structure and composition of gap junction proteins are associated with many kinds of diseases. Movement disorders is a common disease of the central nervous system （CNS）, which has a certain degree of correlation with GJ, and it has become a key factor in the domestic and foreign research of pathogenesis and treatment mechanism of central nervons system diseases. This paper reviews GJ and its relationship with movement disorders.