前列腺癌组织中miR-21的表达及临床意义

Expression of miR-21 in prostate cancer and its clinical significance

目的探讨miR-21在前列腺癌组织中的表达及临床意义。方法采用原位分子杂交技术检测90例前列腺癌组织及69例良性前列腺增生组织中miR-21的表达,并复习相关文献。结果 miR-21在90例前列腺癌及69例良性前列腺增生中的阳性率分别为71.1%、24.6%。miR-21在前列腺癌组织中的表达明显高于良性前列腺增生组织(P<0.05)。miR-21表达与Gleason评分有关(P<0.05),与其他临床病理学因素无关。结论 miR-21在前列腺癌组织中表达上调,提示miR-21可能在前列腺癌的发生、发展过程中发挥重要作用。

Purpose To investigate the expression and clinical significance of microRNA-21 （ miR-21 ） in patients with prostate cancer （PCa）. Methods The human tissue specimens were paraffin-embedded blocks which were collected from the Department of Pathology. miR-21 was detected by in situ hybridization （ISH） in 90 cases of PCa and 69 cases of benign prostatic hyperplasia （BPH）. Results The ISH data showed that the positive rate of miR-21 in PCa （71.1% ） was significantly higher than that in BPH （24. 6% ） （P 〈 0. 05 ）, the expression of miR-21 correlated with the Gleason grade （P 〈 0. 05 ）, and no relationship was observed with other clinicpathological features （P 〉0. 05）. Conclusion The miR-21 plays an important role in the pathogenesis of PCa, which can be a new diagnostic target for PCa.