摘要
目的探讨丁苯酞对卵白蛋白所致支气管哮喘豚鼠模型的影响。方法采用卵白蛋白经致敏与激发两步来复制支气管哮喘豚鼠模型,通过药物干预,观测丁苯酞对哮喘豚鼠的行为学、肺功能、支气管肺泡灌洗液(BALF)中炎性细胞、肺组织病理学及免疫球蛋白E(IgE)的影响。结果 30,60,120 mg·kg^(-1)丁苯酞能降低哮喘豚鼠的哮喘行为学评分、肺组织湿干重比值、BALF中炎性细胞及血清IgE水平,改善肺功能,缓解肺组织病理学变化。结论丁苯酞具有抑制豚鼠肺部炎症而缓解支气管哮喘的作用。
OBJECTIVE To study the effects of butylphthalide on model of bronchial asthma in guinea pigs induced by ovalbumin. METHODS Replicated the model of bronchial asthma in guinea pigs through sensitization and excitation, the effects of butylphthalide were evaluated through behaviors of asthma, pulmonary function, inflammatory cells, Ig E and pulmonary histopathology. RESULTS The 30, 60, 120 mg·kg-（-1） butylphthalide could decrease asthmatic behavior score, lung wet-dry ratio, the number of inflammatory cells in BALF and Ig E in serum, improve lung function, and alleviate the pathological changes of lung tissue. CONCLUSION Butylphthalide has anti-asthma effect on guinea pig partly because of relieving pulmonary inflammation.
作者
王志旺
程小丽
郭玫
任远
王瑞琼
段海婧
刘雪枫
WANG Zhiwang CHENG Xiaoli GUO Mei REN Yuan WANG Ruiqiong DUAN Haijing LIU Xuefengl(Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China Key Laboratory of Pharmacology and Toxicology for Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China)
出处
《中国现代应用药学》
CAS
CSCD
2016年第12期1493-1497,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81460668)
甘肃省自然科学基金项目(1310RJZA086
1606RJZA011)
甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2015-002)
关键词
丁苯酞
哮喘
豚鼠
炎症
butylphthalide
asthma
guinea pig
inflammation
