神经节苷脂对新生儿缺血缺氧性脑病神经行为的影响

Effect of ganglioside on neurobehavioral in hypoxic ischemic encephalopathy

目的探讨神经节苷脂对新生儿缺血缺氧性脑病神经行为的影响。 方法选取2013年3月至2015年3月缺血缺氧性脑病患儿86例，随机分为两组，每组43例，对照组给予常规治疗，观察组在对照组治疗的基础上给予神经节苷脂药物治疗。比较两组患儿的治疗效果及相关评分。 结果观察组治疗有效率高于对照组（93.02%比69.77%），差异有统计学意义（P〈0.05）。观察组IL-6（3.3±0.8）pg/ml、IL-10（14.6±4.3）pg/ml、IL-1β（10.4±4.6）pg/ml水平低于对照组，差异有统计学意义（P〈0.05）；观察组神经行为评分（38.6±9.6）分、Gesell发育量表评分（87.4±10.5）分均高于对照组，差异有统计学意义（P〈0.05）。 结论神经节苷脂能修复缺血缺氧性脑损伤新生儿的细胞损伤，提高患儿神经行为功能。

Objective To investigate the effeicacy of ganglioside on neurobehavioral in hy- poxic ischemic encephalopathy. Methods From March 2013 and March 2015, 86 children with hypoxic ischemic encephalopathy were selected, and were randomly divided into the two groups, with 43 cases in each group. The control group was given routine treatment. On this basis, the observa- tion group was treated with ganglioside. The treatment effect and related score in the two groups were compared. Results The effective rate in the observation group was higher than that in the control group （93.02% vs. 69.77% ） , the difference was significant （ P 〈 0.05 ）. The levels of IL-6 （3.3 ±0.8） pg/ml, IL-10 （14.6±4.3） pg/ml, IL-I[3 （10.4±4.6） pg/ml in the observation group were significantly lower than those in the control group, the differences were significant （ P 〈 0.05）. The neurobehavior score was （38.6±9.6）, the Gesell development score was （ 87.4±10.5 ） in the observation group, which were higher than those in the control group, the differences were significant（ P 〈0. 05 ）. Conclusions Ganglioside can repair ischemia anoxic brain natal cell damage, and can improve children neurobehavioral functions.