血清降钙素原和高敏C反应蛋白在新生儿肺炎合并脓毒症诊断及治疗中的临床价值

Clinical value of of serum procalcitonin and high-sensitivity C-reactive in diagnosis and treatment of neonatal pneumonia and sepsis

目的研究血清降钙素原（PCT）和高敏C反应蛋白（hs-CRP）在新生儿肺炎合并脓毒症诊断及治疗中的临床价值。 方法选择2014年5月31日至2016年2月1日140例新生儿肺炎合并脓毒症的患者，通过脓毒症分级的分类方式分为三组，分别为脓毒症组、严重脓毒症组及脓毒性休克组。观察三组患者的PCT、hs-CRP水平以及APACHEII评分。 结果脓毒症组患者的PCT、hs-CRP水平以及APACHEII评分均明显低于严重脓毒症组和脓毒性休克组患者，差异有统计学意义（P〈0.05）。转诊后肺炎合并脓毒症患者的血清PCT与hs-CRP水平成正比，与APACHEII评分也成正比。 结论 PCT、hs-CRP水平可以判断新生儿肺炎合并脓毒症患者的病情程度，在转诊后对于疗效观察和预后的判断均有较高的应用价值，值得推广应用。

Objective To investigate the clinical value of serum procalcitonin and high-sensitivi- ty C-reactive in diagnosis and treatment of neonatal pneumonia and sepsis. Methods From May 31th, 2014 to February 1st, 2016, 140 cases of neonatal pneumonia sepsis were given detailed discussion and analysis. The 140 patients with neonatal sepsis were divided into three groups by pneumonia sepsis hier- archical classification, the sepsis group, severe sepsis group and septic shock group. The PCT, hs-CRP levels and APACHEII scores were observed. Results The PCT, hs-CRP levels and APACHEII scores in the sepsis group were significantly lower than those in the severe sepsis group and septic shock group, the differences were significant （P 〈 0. 05 ）. After referral, the serum PCT level was positively correlated with the hs-CRP level, and the APACHEⅡ score in the sepsis group. Conclusions The PCT, hs-CRP level can determine the severity of the patient with neonatal pneumonia and sepsis. Meanwhile, after ref-erral, The PCT and hs-CRP levels has important value in the efficacy observation and prognosis judgement, so it is worthy of promotion and use in clinical diagnosis and treatment.