磁共振体素内不相干运动扩散加权成像的原理及应用进展

The basic principle and application progress of intravoxel incoherent motion imaging

体素内不相干运动扩散加权成像（IVIM-DWI）不仅可以获得多种参数（D值、D＊值和f值），而且还具备同时提供扩散与灌注信息、无需对比剂等诸多优势，能够更精细地显示组织微观结构的复杂性，更敏感地体现组织的病理改变，反映疾病的真实性，IVIM-DWI已成为近年来MRI新技术应用研究的热点。笔者以国内外大量文献作为依据，对该技术的基本原理、临床应用现状及进展进行较为全面而简要的阐述。

Intravoxel incoherent motion diffusion-weighted imaging（IVIM-DWI） not only determines various parameters（D value, D＊ value, and f value） but also provides diffusion and perfusion information without the contrast agents. IVIM-DWI can show the complexity of the tissue microstructure in a manner more sophisticated than normal and can reflect with high sensitivity the pathological changes of organization. It can confirm the authenticity of the disease. It has become the focus of research in MRI technology in the recent years. Considering data obtained from a large number of local and international studies, we described comprehensively and briefly the basic principle, status, and progress in clinical applications of IVIM-DWI.