埃索美拉唑与奥美拉唑治疗胃溃疡的疗效对比

Efficacy comparison of esomeprazole and omeprazole in the treatment of gastric ulcer

目的比较埃索美拉唑与奥美拉唑治疗胃溃疡的临床疗效。方法将在我院就诊的82例幽门螺旋杆菌(HP)阳性胃溃疡患者随机分为观察组(埃索美拉唑三联疗法)和对照组(奥美拉唑三联疗法),各41例。对比两组的临床疗效、治疗前后症状积分、不良反应和复发率。结果观察组总有效率(97.56%)显著高于对照组(85.37%)(P<0.05);HP根除率(95.12%)显著高于对照组(80.49%)(P<0.05)。治疗前观察组与对照组症状积分[(7.13±1.64)分vs.(7.15±1.76)分]比较,差异无统计意义(P>0.05);治疗后观察组与对照组症状积分[(1.11±0.93)分vs.(2.13±1.35)分]显著低于治疗前(P<0.05),观察组症状积分[(1.11±0.93)分]显著低于对照组[(2.13±1.35)分](P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。观察组复发率(9.76%)显著低于对照组(24.39%)(P<0.05)。结论埃索美拉唑治疗胃溃疡的临床疗效优于奥美拉唑,不良反应少,复发率低,值得临床推广。

Objective To compare the clinical effects between esomeprazole and omeprazole in the treatment of gastric ulcer. Methods Eighty-two cases of helieobacter pylori （HP） positive patients with gastric ulcer in our hospital were randomly divided into observation group （esomeprazole based triple therapy） and control group （omeprazole based triple therapy）, with 41 eases in each group. The clinical efficacy, symptom scores before and after treatment, adverse reactions and relapse rates between the two groups were compared. Results The total effective rate of the observation group （97.56%） was significantly higher than that of the control group （85.37%） （P〈0.05）; HP eradication rate （95.12%） was significantly higher than that of the control group （80.49%） （P〈0.05）. The difference of symptom scores in the observation group and the control group [（7.13±1.64） vs.（7.15_±1.76）] was not statistically significant before treatment （P〉0.05）; after treatment, symptoms scores of the observation group and the control group [（1.11±0.93） vs. （2.13±1.35）] were significantly lower than those before treatment （P〈0.05）, and the symptoms scores of the observation group （1.11±0.93） was significantly lower than the control group （2.13±1.35） （P〈0.05）. There was no significant difference in adverse reactions between the two groups （P〉0.05）. The recurrence rate of the observation group （9.76%） was significantly lower than that of the control group （24.39%）（P〈0.05）. Conclusion The clinical effect of esomeprazole is better than that of omeprazole in the treatment of gastric ulcer, it has fewer adverse reactions and lower recurrence rate, which is worthy of promotion.