COPD急性加重期患者机械通气治疗中右美托咪定的镇静效果观察

Sedative effect observation of dexmedetomidine in the mechanical ventilation treatment of patients with COPD in acute exacerbation

目的分析右美托咪定在COPD急性加重期患者接受机械通气治疗过程中的镇静效果。方法选取在本院接受机械通气治疗的COPD急性加重期患者110例,根据随机数字表法将患者分为试验组与对照组,各55例。对照组患者给予咪达唑仑镇静治疗,试验组患者接受右美托咪定镇静治疗,比较两组患者的临床效果。结果试验组患者治疗后的呼吸指标、血压指标、停药后清醒时间、入住ICU时间、机械通气时间及不良反应发生率均显著优于对照组,两组比较差异有统计学意义(P<0.05)。结论在COPD急性加重期患者接受机械通气治疗过程中,对患者行右美托咪定镇静,不仅有利于优化患者的呼吸指标、血压指标,缩短患者的治疗周期,还能减少患者不良反应性,临床应用价值显著,值得推广。

Objective To analyze the sedative effect of dexmedetomidine in the mechanical ventilation treatment of patients with COPD in acute exacerbation. Methods One hundred and ten cases of patients with COPD in acute exacerbation who had mechanical ventilation treatment in our hospital were selected, and randomly divided into experiment group and control group according to the random number table metllod, with 55 cases in each group. The control group was treated with midazolam for sedation and the experiment group was treated with dexmedetomidine for sedation. The clinical effects of the two groups were compared. Results After treatment, the respiratory index, blood pressure index, awake time, ICU time, mechanical ventilation time and incidence of adverse reactions in the experiment group were significantly superior to those in the control group, the differences were statistically significant （P〈0.05）. Conclusion For patients with COPD in acute exacerbation during mechanical ventilation treatment, dexmedetomidine for sedation is not only conducive to optimizing the patient＇s respiratory index and blood pressure, shorten the patient＇s treatment cycle, but also reduces the possibility of adverse reactions. The clinical application value is significant, which is worthy of promotion.