早发型重度子痫前期应用硫酸镁和拉贝洛尔联合治疗对血压及妊娠结局的影响

Influence of magnesium sulfate combined with labetalol on blood pressure and pregnancy outcome for patients with early onset severe preeclampsia

目的探究早发型重度子痫前期应用硫酸镁和拉贝洛尔联合治疗对血压及妊娠结局的影响。方法选取2010年1月至2014年12月我院收治的80例早发型重度的子痫前期孕妇,按数字随机抽样法分为研究组和对照组,每组40例。研究组患者给予硫酸镁和拉贝洛尔治疗,对照组患者给予硫酸镁和硝苯地平治疗,观察两组患者的血压变化、孕周延长的时间、新生儿Apgar评分及不良反应发生情况。结果治疗后1 h,研究组患者收缩压及舒张压显著低于对照组(P<0.05);治疗后4 h,两组患者收缩压与舒张压均显著下降,且研究组的收缩压及舒张压下降程度均明显低于对照组(P<0.05);与对照组比较,研究组妊娠终止时间显著延长,研究组新生儿Apgar评分在7分以上比例增加,差异均具有统计学意义(P<0.05)。对照组不良反应发生率为32.50%,明显高于研究组的0.00%(P<0.05)。结论拉贝洛尔联合硫酸镁治疗早发型重度子痫前期具有很好的降压效果,可改善患者的妊娠结局,值得临床推广应用。

Objective To investigate the clinical curative effect of magnesium sulfate combined with labetalol on blood pressure and pregnancy outcome for patients with early onset severe preeclampsia. Methods Eighty cases of patients with early onset severe preeclampsia who were treated in our hospital from January 2010 to December 2014 were selected and randomly divided into study group and control group, with 40 cases in each group. The study group was given magnesium sulfate combined with labetalol, while the control group was treated with magnesium sulfate and nifedipine. The changes of blood pressure, prolonged gestational weeks time, neonatal Apgar score and incidence of adverse reactions of the two groups were compared. Results One hour after the treatment, systolic and diastolic blood pressure of the study group were obviously lower than those of the control group （P〈0.05）. Four hours after the treatment, the systolic pressure and diastolic pressure of the two groups were significantly decreased, and the systolic pressure and diastolic pressure of the study group were significantly lower than those of the control group （P〈0.05）. Compared with the control group, the prolonged gestational weeks time in the study group was longer, the rate of neonatal Apgar score which was more than 7 point was higher, the differences between the two groups was statistically significant （P〈0.05）. The incidence of adverse reactions in the control group was 32.50%, which was obviously higher than 0.00% of the study group （P〈0.05）. Conclusion Labetalol combined with magnesium sulfate has significant effect of reducing pressure in the treatment of early onset severe preeclampsia, which can improve the pregnancy outcomes. It is worthy of clinical popularization and application.