摘要
肺结核是结核分支杆菌(Mycobacterium tuberculosis,MTB)感染引起的重大传染病.固有免疫细胞如巨噬细胞、树突状细胞和自然杀伤细胞等在宿主抵抗MTB入侵过程中发挥了重要作用,多种模式识别受体参与了MTB的识别.本文从固有免疫细胞及其免疫识别受体两个方面综述了结核感染的识别过程,着重探讨了Toll样受体、C型凝集素受体和NOD样受体在MTB识别中的作用机制.
Tuberculosis（TB）,caused by Mycobacterium tuberculosis（MTB）,is still a global public health problem.Innate immunity plays an important role in the host defense against MTB,and the first step in this process is the recognition of MTB by cells of the innate immune system,such as macrophages,dendritic cells and natural killer（NK）cells.Several classes of pattern recognition receptors（PRRs）are involved in the recognition of MTB.We summarized the cells of innate immune and PRRs involved in MTB recognition,and concentrated on the recognized mechanism of PRRs,such as Toll-like receptors,C-type lectin receptors,and Nod-like receptors.
作者
刘金彪
徐瑶
高建峰
周立
LIU Jinbiao XU Yao GAO Jianfeng ZHOU Li(Animal Bio-Safety Level Ⅲ Laboratory at the Center for Animal Experiment, Wuhan University, Wuhan 430071, Hubei, China Institute of Biological and Medicine, Wuhan University of Science and Technology, Wuhan 430081, Hubei, China)
出处
《武汉大学学报（理学版）》
CAS
CSCD
北大核心
2016年第6期495-501,共7页
Journal of Wuhan University:Natural Science Edition
基金
国家自然科学基金(81201261
81301428和81571962)
湖北省自然科学基金(2015CFB164)
中国博士后科学基金(2013M531745和2015M572199)
中央高校基本科研业务费专项(2042015kf0188和2042015kf0017)资助项目
关键词
结核分枝杆菌
模式识别受体
免疫识别
固有免疫
Mycobacterium tuberculosis
pattern recognition receptors
immune recognition
innate immunity
