CYBA基因rs9932581位点多态性与中国汉族人群子痫前期遗传易感性的相关性

CORRELATION BETWEEN CYBA GENE POLYMORPHISMS AND GENETIC PREDISPOSITION OF PREECLAMPSIA IN CHINESE HAN WOMEN

目的探讨烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶p22phox亚基CYBA基因rs9932581位点单核苷酸多态性与中国汉族人群子痫前期的相关性。方法应用实时荧光定量PCR方法,检测1 030例子痫前期病人(病例组)和1 400例健康孕妇(对照组)CYBA基因rs9932581位点多态性。结果对照组与病例组CYBA基因rs9932581多态性基因型及等位基因频率分布差异无显著性(P>0.05);轻度、重度子痫前期病人与对照组比较,基因型和等位基因频率分布差异均无显著性(P>0.05);早发型、晚发型子痫前期病人与对照组比较,基因型和等位基因频率分布差异无显著性(P>0.05);轻度和重度子痫前期病人比较、早发型和晚发型子痫前期病人比较,基因型及等位基因频率分布差异均无显著性(P>0.05)。结论 CYBA基因rs9932581位点多态性与中国汉族人群子痫前期发生无明显相关性。

Objective To investigate the association of Nicotinamide adenine dinucleotide phosphate（NADPH）oxidase p22 phox CYBA gene rs9932581 polymorphism with preeclampsia in Chinese Han women. Methods Employing Quantitative Real-time PCR,the polymorphisms of CYBA gene rs9932581 in 1 030 preeclampsia patients（case group）and 1 400 healthy pregnant women（control group）were detected. Results The genotypic or allelic frequencies at the polymorphic sites were not different between the case group and control group（P〉0.05）.The differences in the genotype and allele frequency distribution in the following circumstances were not significant- between mild or severe preeclampsia patients and healthy controls（P〉0.05）,between the early-onset or late-onset preeclampsia and normal controls（P〉0.05）,and between the early-onset and late-onset preeclampsia（P〉0.05）. Conclusion The genetic variants of rs9932581 in CYBA gene are not associated with preeclampsia.