百草枯应用现状及其对动物的毒性机制研究进展

A Review on Paraquat's Application Status and Its Toxicity Mechanism in Animals

百草枯(PQ)是世界上第二大除草剂,自注册使用以来一直受到农业生产者的喜爱,但多年使用PQ已导致了越来越严重的公共健康问题.之前的研究已对PQ的呼吸、泌尿和神经毒性进行了广泛探讨,提出了多种毒性机制假说,但依据当前知识和技术研发的治疗方法和解毒剂对PQ中毒并没有明显的治疗效果.对PQ应用现状及其动物毒性机制的研究进展进行回顾,期望为进一步评估和预测PQ的使用风险、解析PQ的毒性机制和开发PQ的高效解毒剂提供参考资料和新的研究思路.

Paraquat（PQ）,the second largest herbicide in the world,was always favored by the farmers since it was registered.But for many years,PQ＇s application had caused heavier and heavier public-health issue.Although previous researches widely detected the respiratory,urinary and nervous toxicity of PQ and put forward various kinds of hypothesis about its toxicity mechanism,these treatment methods and antidotes based on current knowledge and technique had no obvious efficacy on PQ intoxication.This paper reviewed PQ＇s application status and its toxicity mechanism in animals,and intended to provide reference material and novel idea for further assessment and prediction of PQ application risk,analysis of PQ toxicity mechanism and exploitation of effective PQ antidote.